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The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes
Citation: Krzyszczyk P, Schloss R, Palmer A and Berthiaume F (2018) The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes.
Before discussing the specifics of M1- and M2-like macrophages, a different categorization will be presented in section Pro-inflammatory, pro-wound Healing and pro- resolving Macrophages-one that separates macrophage phenotype based on their role within the wound healing process.
Pro-inflammatory, Pro-wound Healing, and Pro-resolving Macrophages
In agreement with the phases of wound healing, pro- inflammatory macrophages are present shortly after a wound is formed, followed by pro-wound healing macrophages that support cellular growth and proliferation, and finally pro- resolving macrophages that drastically down-regulate the immune response and aid in collagen reorganization and maturation (Murray and Wynn, 2011; Vannella and Wynn, 2017).
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